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• Activity deltas table
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Motif ID: MEF2{A,B,C,D}.p2

Z-value: 1.129

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr4_-_76944585	5.337	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr7_-_41742666	3.206	NM_002192	INHBA	inhibin, beta A
chr10_+_91152321	3.054	NM_001548	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chr17_-_34207308	2.637	NM_002985	CCL5	chemokine (C-C motif) ligand 5
chr4_-_76957139	2.013	NM_005409	CXCL11	chemokine (C-X-C motif) ligand 11
chr10_+_91092238	1.933	NM_001031683	IFIT3	interferon-induced protein with tetratricopeptide repeats 3
chr10_+_69869249	1.803	NM_032578	MYPN	myopalladin
chr11_+_5710926	1.520		TRIM22	tripartite motif containing 22
chr6_+_127898318	1.441	NM_001010905	C6orf58	chromosome 6 open reading frame 58
chr10_+_111765725	1.419	NM_019903	ADD3	adducin 3 (gamma)
chr8_+_120079423	1.309	NM_006438	COLEC10	collectin sub-family member 10 (C-type lectin)
chr2_+_168043792	1.270	NM_001199144 NM_001199145	XIRP2	xin actin-binding repeat containing 2
chr10_-_75401199	1.242		MYOZ1	myozenin 1
chr4_+_89299874	1.242	NM_001165136 NM_017912	HERC6	hect domain and RLD 6
chr1_+_15990300	1.238
chr1_+_28585959	1.228	NM_031459	SESN2	sestrin 2
chr21_+_27011588	1.211	NM_021219	JAM2	junctional adhesion molecule 2
chr11_+_69467210	1.198		CCND1	cyclin D1
chr17_-_39280377	1.195	NM_031854	KRTAP4-12	keratin associated protein 4-12
chr17_-_74483806	1.190	NM_001005498	RHBDF2	rhomboid 5 homolog 2 (Drosophila)
chr10_-_69455926	1.182	NM_013266	CTNNA3	catenin (cadherin-associated protein), alpha 3
chr1_+_175036993	1.145	NM_022093	TNN	tenascin N
chr1_-_150738255	1.118		CTSS	cathepsin S
chr12_-_105322056	1.104	NM_032148	SLC41A2	solute carrier family 41, member 2
chr11_+_5710816	1.103	NM_001199573 NM_006074	TRIM22	tripartite motif containing 22
chr10_-_75401492	1.090	NM_021245	MYOZ1	myozenin 1
chr1_-_32281577	1.090	NM_144569	SPOCD1	SPOC domain containing 1
chr16_+_84328400	1.084	NM_021197	WFDC1	WAP four-disulfide core domain 1
chr12_-_111358353	1.071	NM_000432	MYL2	myosin, light chain 2, regulatory, cardiac, slow
chr6_+_34204928	1.060		HMGA1	high mobility group AT-hook 1
chr8_+_104831415	1.058	NM_014677	RIMS2	regulating synaptic membrane exocytosis 2
chr14_-_61748510	1.056	NM_001017970	TMEM30B	transmembrane protein 30B
chr12_+_7942025	1.019		NANOG	Nanog homeobox
chr4_-_155312448	0.989	NM_017639	DCHS2	dachsous 2 (Drosophila)
chr4_+_100495972	0.943		MTTP	microsomal triglyceride transfer protein
chr2_-_10588451	0.934	NM_002539	ODC1	ornithine decarboxylase 1
chr3_-_39234071	0.896	NM_194293 NM_001198621	XIRP1	xin actin-binding repeat containing 1
chr10_-_14372807	0.895	NM_018027	FRMD4A	FERM domain containing 4A
chr19_-_49576120	0.890	NM_031886	KCNA7	potassium voltage-gated channel, shaker-related subfamily, member 7
chr2_-_163099877	0.879	NM_004460	FAP	fibroblast activation protein, alpha
chr7_-_107880492	0.856	NM_001037132	NRCAM	neuronal cell adhesion molecule
chr1_-_158656487	0.843	NM_003126	SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr5_+_161275185	0.835		GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_+_69201845	0.825	NM_002392	MDM2	Mdm2 p53 binding protein homolog (mouse)
chr6_-_134639195	0.819	NM_001143676	SGK1	serum/glucocorticoid regulated kinase 1
chr19_+_15904760	0.815	NM_001004466	OR10H5	olfactory receptor, family 10, subfamily H, member 5
chr3_-_145878775	0.813		PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr1_+_170633312	0.810	NM_006902 NM_022716	PRRX1	paired related homeobox 1
chr12_-_16759939	0.809	NM_001243613	LMO3	LIM domain only 3 (rhombotin-like 2)
chr5_-_58652671	0.807	NM_001197219	PDE4D	phosphodiesterase 4D, cAMP-specific
chr5_-_35938736	0.804	NM_001042625 NM_144647	CAPSL	calcyphosine-like
chr13_-_34250899	0.799	NM_001243476	STARD13	StAR-related lipid transfer (START) domain containing 13
chr1_-_100643770	0.794	NM_144620	LRRC39	leucine rich repeat containing 39
chr17_+_34431219	0.782	NM_002984	CCL4	chemokine (C-C motif) ligand 4
chr2_-_148779172	0.769	NM_181742	ORC4	origin recognition complex, subunit 4
chrX_-_11284094	0.769	NM_013423	ARHGAP6	Rho GTPase activating protein 6
chr6_+_7108184	0.765		RREB1	ras responsive element binding protein 1
chr3_-_57326709	0.761	NM_001142733	ASB14	ankyrin repeat and SOCS box containing 14
chr2_-_10588273	0.759		ODC1	ornithine decarboxylase 1
chr1_+_74701070	0.758	NM_015978	TNNI3K	TNNI3 interacting kinase
chr7_+_18126543	0.735	NM_001204144	HDAC9	histone deacetylase 9
chr17_-_29648631	0.717	NM_001003927 NM_014210	EVI2A	ecotropic viral integration site 2A
chr14_-_53162418	0.715	NM_014584	ERO1L	ERO1-like (S. cerevisiae)
chr1_-_116311398	0.707	NM_001232	CASQ2	calsequestrin 2 (cardiac muscle)
chr1_-_116311161	0.705		CASQ2	calsequestrin 2 (cardiac muscle)
chr18_+_12407894	0.705	NM_001142405 NM_006553	SLMO1	slowmo homolog 1 (Drosophila)
chr1_-_205912546	0.701	NM_052934 NM_134325	SLC26A9	solute carrier family 26, member 9
chr1_-_116311330	0.693		CASQ2	calsequestrin 2 (cardiac muscle)
chr12_+_109554391	0.693		ACACB	acetyl-CoA carboxylase beta
chr2_-_133429069	0.685	NM_001077427	LYPD1	LY6/PLAUR domain containing 1
chr6_-_32806452	0.678		TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_+_42727010	0.675	NM_152393	KBTBD5	kelch repeat and BTB (POZ) domain containing 5
chr7_+_18535351	0.670	NM_001204145 NM_001204146 NM_014707 NM_178423	HDAC9	histone deacetylase 9
chr2_-_69180011	0.668	NM_182536	GKN2	gastrokine 2
chr10_+_71561687	0.664		COL13A1	collagen, type XIII, alpha 1
chr6_-_32806545	0.664	NM_000544 NM_018833	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_+_55095433	0.663		PDGFRA	platelet-derived growth factor receptor, alpha polypeptide
chr19_+_40194945	0.661	NM_020129 NM_203471	LGALS14	lectin, galactoside-binding, soluble, 14
chr12_-_16760935	0.652	NM_001001395 NM_001243609	LMO3	LIM domain only 3 (rhombotin-like 2)
chr11_-_47400096	0.634	NM_001080547 NM_003120	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr22_+_21128378	0.629	NM_000185	SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_+_203097427	0.627		ADORA1	adenosine A1 receptor
chr21_-_19775958	0.619	NM_002772	TMPRSS15	transmembrane protease, serine 15
chr5_+_155753755	0.613	NM_000337 NM_001128209 NM_172244	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr1_-_206945725	0.611	NM_000572	IL10	interleukin 10
chr11_-_1629614	0.600	NM_001012708	KRTAP5-3	keratin associated protein 5-3
chr16_+_57673206	0.593	NM_001145774	GPR56	G protein-coupled receptor 56
chr5_-_95748688	0.585	NM_001177876	PCSK1	proprotein convertase subtilisin/kexin type 1
chr2_-_211168315	0.582	NM_079422	MYL1	myosin, light chain 1, alkali; skeletal, fast
chrX_-_63450486	0.578	NM_130388	ASB12	ankyrin repeat and SOCS box containing 12
chr12_-_16758312	0.576	NM_001243611	LMO3	LIM domain only 3 (rhombotin-like 2)
chr14_+_23352430	0.571	NM_173527	REM2	RAS (RAD and GEM)-like GTP binding 2
chr1_+_13911966	0.567	NM_001006624 NM_001006625	PDPN	podoplanin
chr11_-_84634219	0.561		DLG2	discs, large homolog 2 (Drosophila)
chr9_-_130540911	0.555	NM_170600	SH2D3C	SH2 domain containing 3C
chr1_-_59249687	0.554	NM_002228	JUN	jun proto-oncogene
chr17_+_41132587	0.553		RUNDC1	RUN domain containing 1
chr5_+_148731226	0.550		GRPEL2	GrpE-like 2, mitochondrial (E. coli)
chr1_-_33430285	0.549	NM_001127361 NM_153341	RNF19B	ring finger protein 19B
chr3_-_192445344	0.549	NM_004113	FGF12	fibroblast growth factor 12
chr14_+_32798478	0.547	NM_004274	AKAP6	A kinase (PRKA) anchor protein 6
chr17_+_41132581	0.541	NM_173079	RUNDC1	RUN domain containing 1
chr3_+_50316517	0.540	NM_153215	C3orf45	chromosome 3 open reading frame 45
chr1_+_151129104	0.538	NM_001204848 NM_024575	TNFAIP8L2-SCNM1 TNFAIP8L2	TNFAIP8L2-SCNM1 readthrough tumor necrosis factor, alpha-induced protein 8-like 2
chr6_+_64356430	0.529	NM_015153	PHF3	PHD finger protein 3
chr12_-_16759531	0.526	NM_018640	LMO3	LIM domain only 3 (rhombotin-like 2)
chr15_+_100173182	0.526	NM_001130928	MEF2A	myocyte enhancer factor 2A
chr12_+_7941994	0.525	NM_024865	NANOG	Nanog homeobox
chr7_+_129906702	0.522	NM_001869	CPA2	carboxypeptidase A2 (pancreatic)
chr12_+_69201979	0.521		MDM2	Mdm2 p53 binding protein homolog (mouse)
chr6_-_33160199	0.519	NM_001163771 NM_080679 NM_080680 NM_080681	COL11A2	collagen, type XI, alpha 2
chr20_+_48807365	0.517		CEBPB	CCAAT/enhancer binding protein (C/EBP), beta
chr11_-_47399903	0.515
chr4_-_169239816	0.515	NM_017631	DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr8_-_119964059	0.514	NM_002546	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b
chr11_+_131240370	0.508	NM_001048209	NTM	neurotrimin
chr4_-_21699317	0.508	NM_001035003	KCNIP4	Kv channel interacting protein 4
chr7_-_135613197	0.506		LUZP6	leucine zipper protein 6
chr10_+_71561643	0.497	NM_001130103 NM_080798 NM_080800 NM_080801 NM_080802 NM_080805	COL13A1	collagen, type XIII, alpha 1
chr15_-_72501017	0.493		PKM2	pyruvate kinase, muscle
chr8_-_90996785	0.493		NBN	nibrin
chr12_+_81101407	0.492	NM_002469	MYF6	myogenic factor 6 (herculin)
chr2_+_152214105	0.489	NM_007115	TNFAIP6	tumor necrosis factor, alpha-induced protein 6
chr1_+_25757381	0.487	NM_018202	TMEM57	transmembrane protein 57
chr11_+_35965530	0.487	NM_174902	LDLRAD3	low density lipoprotein receptor class A domain containing 3
chr2_-_190044330	0.487	NM_000393	COL5A2	collagen, type V, alpha 2
chr18_+_32073343	0.483		DTNA	dystrobrevin, alpha
chr4_+_175839508	0.479	NM_001130703 NM_001130704 NM_001130705 NM_014269	ADAM29	ADAM metallopeptidase domain 29
chr9_+_5231401	0.478	NM_002195	INSL4	insulin-like 4 (placenta)
chr3_+_111717585	0.477	NM_001008272 NM_013259	TAGLN3	transgelin 3
chr12_-_16759430	0.476		LMO3	LIM domain only 3 (rhombotin-like 2)
chr4_+_15429628	0.474	NM_031911	C1QTNF7	C1q and tumor necrosis factor related protein 7
chr12_+_55413728	0.471	NM_021191	NEUROD4	neurogenic differentiation 4
chr20_+_5987897	0.469	NM_001127458	CRLS1	cardiolipin synthase 1
chr14_-_70546863	0.469	NM_182936 NM_001130417	SLC8A3	solute carrier family 8 (sodium/calcium exchanger), member 3
chr17_-_48945338	0.469	NM_001243877	TOB1	transducer of ERBB2, 1
chr8_-_27115897	0.467	NM_030795	STMN4	stathmin-like 4
chr11_+_45115563	0.464	NM_020229	PRDM11	PR domain containing 11
chrX_-_21776158	0.462	NM_014332	SMPX	small muscle protein, X-linked
chr16_+_29471206	0.461	NM_001017390 NM_177552	SULT1A4 SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr6_+_7108864	0.461		RREB1	ras responsive element binding protein 1
chr5_-_16509106	0.461	NM_019000	FAM134B	family with sequence similarity 134, member B
chr9_-_85882093	0.460	NM_001244962	FRMD3	FERM domain containing 3
chr4_+_70916158	0.458	NM_002159	HTN1	histatin 1
chr14_-_23877480	0.452	NM_002471	MYH6	myosin, heavy chain 6, cardiac muscle, alpha
chr2_+_170366211	0.445	NM_006063	KBTBD10	kelch repeat and BTB (POZ) domain containing 10
chr2_+_29038862	0.445	NM_001008779	SPDYA	speedy homolog A (Xenopus laevis)
chr22_+_36044412	0.442	NM_030641	APOL6	apolipoprotein L, 6
chr12_-_46633551	0.441		SLC38A1	solute carrier family 38, member 1
chr7_-_124430742	0.441	NM_001024603	LOC154872	uncharacterized LOC154872
chr6_+_131571298	0.436	NM_004842 NM_138633	AKAP7	A kinase (PRKA) anchor protein 7
chr16_+_30210548	0.435	NM_001017390 NM_177552	SULT1A4 SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr17_+_34538464	0.434	NM_207007 NM_001001435	CCL4L2 CCL4L1	chemokine (C-C motif) ligand 4-like 2 chemokine (C-C motif) ligand 4-like 1
chr17_+_41363845	0.433	NM_145041	TMEM106A	transmembrane protein 106A
chr9_-_14722669	0.431	NM_005454	CER1	cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr12_-_122240827	0.430
chr17_-_1389013	0.429	NM_001080950	MYO1C	myosin IC
chr8_-_27115935	0.428		STMN4	stathmin-like 4
chr4_+_76995862	0.422	NM_001130016 NM_001179	ART3	ADP-ribosyltransferase 3
chr15_+_100106214	0.417		MEF2A	myocyte enhancer factor 2A
chr14_-_65409445	0.417	NM_002083	GPX2	glutathione peroxidase 2 (gastrointestinal)
chr19_+_7504573	0.415	NM_001130955	ARHGEF18	Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr5_+_121465214	0.413	NM_207317	ZNF474	zinc finger protein 474
chr1_+_44870926	0.412	NM_018150	RNF220	ring finger protein 220
chr20_+_9288446	0.412	NM_000933	PLCB4	phospholipase C, beta 4
chr3_+_127641901	0.407	NM_207335	KBTBD12	kelch repeat and BTB (POZ) domain containing 12
chr1_+_90098624	0.407		LRRC8C	leucine rich repeat containing 8 family, member C
chr2_+_233498206	0.405	NM_025202	EFHD1	EF-hand domain family, member D1
chr11_-_51412447	0.404	NM_001005272	OR4A5	olfactory receptor, family 4, subfamily A, member 5
chr6_+_132891460	0.404	NM_175067	TAAR6	trace amine associated receptor 6
chr1_-_115238091	0.399	NM_000036 NM_001172626	AMPD1	adenosine monophosphate deaminase 1
chr2_-_151344145	0.399	NM_005168	RND3	Rho family GTPase 3
chr1_-_182369750	0.396	NM_172000	TEDDM1	transmembrane epididymal protein 1
chr5_-_142077508	0.394	NM_001144934 NM_001144935	FGF1	fibroblast growth factor 1 (acidic)
chr11_-_19223516	0.392	NM_001127656 NM_003476	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr15_+_100106132	0.391	NM_001130926 NM_001130927 NM_001171894 NM_005587	MEF2A	myocyte enhancer factor 2A
chr1_-_7913094	0.391	NM_006786	UTS2	urotensin 2
chr18_+_61554938	0.389	NM_001143818 NM_002575	SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr3_-_145878936	0.387		PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr11_+_65082288	0.387	NM_006779	CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2
chr5_-_142065586	0.383	NM_000800	FGF1	fibroblast growth factor 1 (acidic)
chr2_-_55199894	0.382
chr12_-_131200818	0.382		RIMBP2	RIMS binding protein 2
chr3_+_97868169	0.381	NM_001005514	OR5H14	olfactory receptor, family 5, subfamily H, member 14
chr19_-_4302381	0.380	NM_001169126 NM_144615	TMIGD2	transmembrane and immunoglobulin domain containing 2
chr22_-_30642683	0.380	NM_002309	LIF	leukemia inhibitory factor (cholinergic differentiation factor)
chr3_+_9691198	0.379		MTMR14	myotubularin related protein 14
chr10_+_80899458	0.379		ZMIZ1	zinc finger, MIZ-type containing 1
chr8_-_70745624	0.376	NM_001146008	SLCO5A1	solute carrier organic anion transporter family, member 5A1
chr14_+_95078713	0.376	NM_001085	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr22_-_24096551	0.376	NM_013378	VPREB3	pre-B lymphocyte 3
chrX_-_15332680	0.375	NM_001012428	ASB11	ankyrin repeat and SOCS box containing 11
chr1_+_39922262	0.368		MACF1	microtubule-actin crosslinking factor 1
chr1_+_244515936	0.366	NM_001012970	C1orf100	chromosome 1 open reading frame 100
chr13_-_52980628	0.366	NM_018676 NM_199263	THSD1	thrombospondin, type I, domain containing 1
chr8_-_110342107	0.364	NM_001128211	NUDCD1	NudC domain containing 1
chr15_+_100106179	0.364		MEF2A	myocyte enhancer factor 2A
chr12_-_371994	0.364	NM_001190997 NM_001243392 NM_016615	SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr15_+_74286999	0.364	NM_002675 NM_033238 NM_033239 NM_033240 NM_033244 NM_033246 NM_033247 NM_033249 NM_033250	PML	promyelocytic leukemia
chr22_-_17690778	0.363	NM_017424	CECR1	cat eye syndrome chromosome region, candidate 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.97	9.04e-04	GO:0006873	cellular ion homeostasis
2.18	1.08e-03	GO:0030003	cellular cation homeostasis
2.12	1.12e-03	GO:0055080	cation homeostasis
1.94	1.35e-03	GO:0055082	cellular chemical homeostasis
1.91	1.36e-03	GO:0050801	ion homeostasis
2.19	2.83e-03	GO:0006875	cellular metal ion homeostasis
2.17	2.89e-03	GO:0055065	metal ion homeostasis
1.75	3.88e-03	GO:0048878	chemical homeostasis
2.46	4.43e-03	GO:0003012	muscle system process
1.19	1.27e-02	GO:0032501	multicellular organismal process
4.28	2.71e-02	GO:0030049	muscle filament sliding
4.28	2.71e-02	GO:0033275	actin-myosin filament sliding
4.17	3.69e-02	GO:0070252	actin-mediated cell contraction
1.71	3.96e-02	GO:0019725	cellular homeostasis
2.34	4.99e-02	GO:0006936	muscle contraction

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
3.42	5.81e-07	GO:0030016	myofibril
3.22	2.60e-06	GO:0043292	contractile fiber
3.50	4.00e-06	GO:0030017	sarcomere
3.27	5.67e-06	GO:0044449	contractile fiber part
1.64	1.34e-05	GO:0044421	extracellular region part
1.58	3.84e-03	GO:0005615	extracellular space
1.32	1.15e-02	GO:0005576	extracellular region

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.67	1.91e-02	GO:0008092	cytoskeletal protein binding